Helllllllllllllp! The liver ...?
Hey there,
I'm getting a little confused about the liver.
In my awareness, amino acids - once they are absorbed into the bloodstream via the small intestine - are generally good things to hold around; from the bloodstream they go to muscles, they go to cells to assist manufacture other proteins, etcetera.
Yet the liver is all about (amongst other things) the deanimation of amino acids into ammonia. Ammonia is a toxic substance to enjoy in the body and is therefore excreted via the Urea cycle.
Basically, my point is, why would the liver deanimate an amino acid if it's adjectives and the body likes to have it around? Is it because once an amino acid hits the liver it unambiguously circulated through the body and wasn't needed, or what?
Answers:
AA do have to be broken done into their essential product before the body gets rid of the ammonia component., if they are not ..other process will covert this aminoacid form into a toxic ammonia ...so to prevent observable fact like this the liver helps to complete the process by deamminating the AA into the ammonia so the toxic ammonia can be excreted by the kidney .....when the aa are absorbed through the intestinal wall..they run straight into the Heportal vein and to the liver ...not muscle., we dont have AA in the muscle only fats and glycogen ...for long term energy storage
Many amino acids come from diet and are not manufactured but taken up into cell for various purposes (e.g., tyrosine is converted to norepinephrine used in the brain and elsewhere; l-Dopa is similarly converted to dopamine). However, all tissues can synthesize non-essential amino acids to some level, mostly by converting carbon (from any number of sources) into amino acids and other derivatives that contain nitrogen. Regardless of the source of amino acids, when there is excess nitrogen from amino acids, it is the nitrogen that is deaminated by the liver and excreted (urea). So, the body needs amino acids but their production (within the body) or ingestion (from diet) can result contained by excess nitrogen which as you point out, is toxic. Source(s): I am a forensic psychopharmacologist, author of several texts and taught physiology and pharmacokinetics for many years.
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I'm getting a little confused about the liver.
In my awareness, amino acids - once they are absorbed into the bloodstream via the small intestine - are generally good things to hold around; from the bloodstream they go to muscles, they go to cells to assist manufacture other proteins, etcetera.
Yet the liver is all about (amongst other things) the deanimation of amino acids into ammonia. Ammonia is a toxic substance to enjoy in the body and is therefore excreted via the Urea cycle.
Basically, my point is, why would the liver deanimate an amino acid if it's adjectives and the body likes to have it around? Is it because once an amino acid hits the liver it unambiguously circulated through the body and wasn't needed, or what?
Answers:
AA do have to be broken done into their essential product before the body gets rid of the ammonia component., if they are not ..other process will covert this aminoacid form into a toxic ammonia ...so to prevent observable fact like this the liver helps to complete the process by deamminating the AA into the ammonia so the toxic ammonia can be excreted by the kidney .....when the aa are absorbed through the intestinal wall..they run straight into the Heportal vein and to the liver ...not muscle., we dont have AA in the muscle only fats and glycogen ...for long term energy storage
Many amino acids come from diet and are not manufactured but taken up into cell for various purposes (e.g., tyrosine is converted to norepinephrine used in the brain and elsewhere; l-Dopa is similarly converted to dopamine). However, all tissues can synthesize non-essential amino acids to some level, mostly by converting carbon (from any number of sources) into amino acids and other derivatives that contain nitrogen. Regardless of the source of amino acids, when there is excess nitrogen from amino acids, it is the nitrogen that is deaminated by the liver and excreted (urea). So, the body needs amino acids but their production (within the body) or ingestion (from diet) can result contained by excess nitrogen which as you point out, is toxic. Source(s): I am a forensic psychopharmacologist, author of several texts and taught physiology and pharmacokinetics for many years.
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