How does the body’s immune system mobilize for rejection of a transplanted organ?
How does the body’s immune system mobilize for rejection of a transplanted organ?
Answers:
dosnt it just start attacking it like any other foreign body? is that why theres a need for meds?
The body's response to a transplanted organ is alike as the immune response to any antigen or foreign body.
The general immune response involves the body's ability to destroy invading microorganisms and and nonliving foreign natural materials through the action of certain white blood corpuscles and antibodies in the blood. The production of antibodies to brawl the antigens, or foreign substance(s) is at stake. An antibody is a specific substance produced by tissues of the body when they are stimulated by an antigen, examples of which are bacteria, toxins and foreign proteins, and capable of neutralizing or giving imperviousness against the specific antigen. The antibodies react in the bloodstream with the invading materials, which are call antigens.. The antigens are thus neutralized. Natural immunity results from the inherent ability of the body to produce trustworthy kinds of antibodies. Antibodies are not produced in the blood. They are produced in the tissues of the body, from which they may be released into the bloodstream. The antigens are neutralize by the antibodies inside the bloodstream. No clinical reaction should occur in the process, when imperviousness exists. When this neutralization occurs in the tissues,, a violent hypersensitivity called anaphylaxis may take place.
At the heart of the matter of rejection of transplanted tissues is a mismatched HLA antigen. These antigens hold many alleles, making an exact match between a donor and recipient near identical antigens nearly impossible.
Acute rejection mainly sets in inside a week of a transplant.
The Wikipedia web site has the following to add on the subject of the process of rejection:
START
Tissues such as the kidney or the liver which are highly vascularized (rich in blood vessels), are often the earliest victims of acute rejection. In certainty, episodes of acute rejection occur in around 60-75% of first kidney transplants, and 50 to 60% of liver transplants. Damage to the endothelial lining of blood vessel is an early predictor of irreversible acute transplant rejection.
The reason acute rejection usually begins one week after transplantation is that T-cells are involved surrounded by the rejection mechanism. These T-cells must differentiate before rejection begins. The T-cells result in cells in the transplanted tissue to lyse, or produce cytokines that cause necrosis of the transplanted tissue.
END
More specific information can be found at Wikipedia among other sources.
http://www.en.wikipedia.org/wiki/Transpl… Source(s): Link already provided
'The Columbia-Viking Desk Encyclopedia', Volume One, page 45, 503
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Answers:
dosnt it just start attacking it like any other foreign body? is that why theres a need for meds?
The body's response to a transplanted organ is alike as the immune response to any antigen or foreign body.
The general immune response involves the body's ability to destroy invading microorganisms and and nonliving foreign natural materials through the action of certain white blood corpuscles and antibodies in the blood. The production of antibodies to brawl the antigens, or foreign substance(s) is at stake. An antibody is a specific substance produced by tissues of the body when they are stimulated by an antigen, examples of which are bacteria, toxins and foreign proteins, and capable of neutralizing or giving imperviousness against the specific antigen. The antibodies react in the bloodstream with the invading materials, which are call antigens.. The antigens are thus neutralized. Natural immunity results from the inherent ability of the body to produce trustworthy kinds of antibodies. Antibodies are not produced in the blood. They are produced in the tissues of the body, from which they may be released into the bloodstream. The antigens are neutralize by the antibodies inside the bloodstream. No clinical reaction should occur in the process, when imperviousness exists. When this neutralization occurs in the tissues,, a violent hypersensitivity called anaphylaxis may take place.
At the heart of the matter of rejection of transplanted tissues is a mismatched HLA antigen. These antigens hold many alleles, making an exact match between a donor and recipient near identical antigens nearly impossible.
Acute rejection mainly sets in inside a week of a transplant.
The Wikipedia web site has the following to add on the subject of the process of rejection:
START
Tissues such as the kidney or the liver which are highly vascularized (rich in blood vessels), are often the earliest victims of acute rejection. In certainty, episodes of acute rejection occur in around 60-75% of first kidney transplants, and 50 to 60% of liver transplants. Damage to the endothelial lining of blood vessel is an early predictor of irreversible acute transplant rejection.
The reason acute rejection usually begins one week after transplantation is that T-cells are involved surrounded by the rejection mechanism. These T-cells must differentiate before rejection begins. The T-cells result in cells in the transplanted tissue to lyse, or produce cytokines that cause necrosis of the transplanted tissue.
END
More specific information can be found at Wikipedia among other sources.
http://www.en.wikipedia.org/wiki/Transpl… Source(s): Link already provided
'The Columbia-Viking Desk Encyclopedia', Volume One, page 45, 503
Related Questions: