Do caffeine and Medication lately plain not affect some inhabitants?
I drank an Arizona with caffeine in it, a 5 hour energy, a coffee, and chewed life gum...in all it was around 8-10,000mg of caffeine, and I be totally normal. Nothing happens with caffeine, I sleep fine, I don't attain hyper. The same thing with medicine! Advil and Ibuprofen don't comfort me ever and I take up to 5. The only time medicine really help me is when it's directly injected or inhaled, like laughing gas and stuff they put through IV's. Just wondering what your opinions are, if the effects just aren't noticable or what:). Thanks
Answers:
I'm the exact same. Caffeine doesn't really affect me.
Hi
It can happen that even if a person is having a sensitivity to a substance it can be 'masked' by other factors.
Exclusion diets can reveal the true extent of a reaction.
There is like mad of variation between people with respect to drug response. Part of this variability is caused by different metabolic clearance rates of the drug. Drugs are chemically oxidized by enzymes in the liver, which makes them more wet soluble, which allows you to pee them out. If you couldn't do this, drugs would stay in your body for a very long time, if not forever.
Caffeine is call a "stimulant" but in reality it only blocks your brain from reception the signal that you are tired. It can not make you more energetic than normal, and nation who claim it does are experiencing the placebo effect because popular culture believes that this is what caffeine does.
Caffeine is also metabolized in the liver by the enzyme: cytochrome P450 1A2 (or CYP1A2). Some people are slow metabolizers while others are moderate and some are fast. This depends on what gene you hold for this enzyme. It sounds like you may be a CYP1A2 fast metabolizer, congratulations! This will make you smaller number sensitive to many medications. Check out the CYP1A2 substrates in the following interconnect. Also, if you regularly consume caffeine, you will become tolerant to its effects.
Advil and Ibuprofen are the same thing (advil is a brand). This drug is metabolized by CYP2C9. There are also fast and slow version of this gene/enzyme. There may be something similar going on with your reaction to ibuprofen. That is, you might be metabolizing it to the inactive form past it gets a chance to do its job. But, if you are taking this medication for something that won't be help by ibuprofen (a common mistake) then you won't see an effect.
Over the counter medications are commonly ineffective because of interpersonal variation in metabolism. But, these drugs are usually very locked, and it is not required to determine your unique personalized dose (but medicine is moving this direction). Laughing gas and IV drugs that are used in hospitals are a different story. They can be unbelievably dangerous and they require special work by the doctors to determine your particular dose. Laughing gas and other anesthetics are dosed and monitored with extreme precision by anesthesiologists, which is why you spot the effect.
http://www.pharmacytimes.com/issues/arti…
http://en.wikipedia.org/wiki/Caffeine#To…
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Answers:
I'm the exact same. Caffeine doesn't really affect me.
Hi
It can happen that even if a person is having a sensitivity to a substance it can be 'masked' by other factors.
Exclusion diets can reveal the true extent of a reaction.
There is like mad of variation between people with respect to drug response. Part of this variability is caused by different metabolic clearance rates of the drug. Drugs are chemically oxidized by enzymes in the liver, which makes them more wet soluble, which allows you to pee them out. If you couldn't do this, drugs would stay in your body for a very long time, if not forever.
Caffeine is call a "stimulant" but in reality it only blocks your brain from reception the signal that you are tired. It can not make you more energetic than normal, and nation who claim it does are experiencing the placebo effect because popular culture believes that this is what caffeine does.
Caffeine is also metabolized in the liver by the enzyme: cytochrome P450 1A2 (or CYP1A2). Some people are slow metabolizers while others are moderate and some are fast. This depends on what gene you hold for this enzyme. It sounds like you may be a CYP1A2 fast metabolizer, congratulations! This will make you smaller number sensitive to many medications. Check out the CYP1A2 substrates in the following interconnect. Also, if you regularly consume caffeine, you will become tolerant to its effects.
Advil and Ibuprofen are the same thing (advil is a brand). This drug is metabolized by CYP2C9. There are also fast and slow version of this gene/enzyme. There may be something similar going on with your reaction to ibuprofen. That is, you might be metabolizing it to the inactive form past it gets a chance to do its job. But, if you are taking this medication for something that won't be help by ibuprofen (a common mistake) then you won't see an effect.
Over the counter medications are commonly ineffective because of interpersonal variation in metabolism. But, these drugs are usually very locked, and it is not required to determine your unique personalized dose (but medicine is moving this direction). Laughing gas and IV drugs that are used in hospitals are a different story. They can be unbelievably dangerous and they require special work by the doctors to determine your particular dose. Laughing gas and other anesthetics are dosed and monitored with extreme precision by anesthesiologists, which is why you spot the effect.
http://www.pharmacytimes.com/issues/arti…
http://en.wikipedia.org/wiki/Caffeine#To…
Related Questions: