Intra-hepatic jaundice....conjugated or unconjugated hyperbilirubinaemia?

With intra-hepatic jaundice, is the excess bilirubin mostly unconjugated or conjugated? My first thought is that it would be mostly unconjugated because the liver is damaged, so less bilirubin is being processed, however I enjoy read different things from different sources.
Answers:
Depends on the cause, but yes usually it would be unconjugated, as bilirubin conjugation and excretion into bile occur together and the process is quite energy-dependent, so it slows right down next to intra-hepatic jaundice. Obstructive jaundice (e.g. Ca head of pancreas etc) usually has conjugated bilirubin, since the liver is still able to conjugate it OK. Source(s): biochemist

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