What are the clinical implication to the reality that warfarin is metabolized by cytochrome P450 enzymes?
Answers:
Many medications affect the P450 pathway. Some increase the metabolism, some reduce it.
Depending on the medicine, the warfarin height (INR) would go up or down. Source(s): vascular surgery PA
It (warfarin) can interfere with the metabolism of other drugs that use the P450 system or the presence of other drugs can interfere with the bioavailability of warfarin. Alcohol, for example is metabolized by the CY P 450 system contained by alcoholics or at least chronic drinkers. In this case, drinking alcohol would affect the availability of warfarin. It depends on which drug is preferentially metabolized by the enzyme. Source(s): I am a forensic psychopharmacologist, author of several books, and taught neuropharm for plentiful years.
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