A drug that inhibits Na+/K+ pump is given to a merciful?What effects would if own on nephron?
How would it effect nephron reabsorbtion of amino acids?
Answers:
I do not know anysubstance that inhibit Na+/K+ pump in the nephron.
But Na+/K+ 2 Cl- inhibitors like furosimide at the thick ascending limb( dampen pill ) cause more water to be excreted. Inhibitors like triamteride ( K+ sparing ) inhibits Na+/ K+ exchange at the collecting ducts. Both increase the concentration of solutes within the tubular fluids an cause diuresis.
Aminoacids are reabsorbed with sodium in the proximal tubules. Inhibition of Na+/K+ pump will increase intra cellular sodium and as a consequence can indirectly inhibit its absorption. Source(s): http://en.wikipedia.org/wiki/Diuretic
the Na/K pump has been call a pace maker of cellular respiration, accounting for 1/2 of all respiration within the body. (discussion of thyroid hormone effects on ATPase concentrations in cells found in "Foye's Principles of Medicinal Chemistry, 2nd edition, Chapter 26 by Nicolas Zenker).
"The bulk of adjectives transport in the kidney is due to the abundant supply of Na+,K+ - ATPase in the basolateral membranes of the renal epithelial cell and the separation of Na+ and K+ across the cell membrane." (Pharmacology text listed below)
You would expect Organic Acid and Organic Base transport (powered by the Sodium pump) to cease, and that alone would murder the patient.
I have not carefully studied the topic, I am freshly picking out what I have skimmed from a brief reading. Source(s): Goodman and Gilman's The Pharmacological Basis of Therapeutics, 11th edition, page 740-741. See chapter 28 written by Edwin K. Jackson, but before you do that read a little contained by chapter 1 regarding cell membrane and transport through membranes.
Related Questions:
Are nearby any over the counter diet pills that in fact work?
What is the difference between budeprion and abilify?
In the event of an ambulance hold up and damp squib of heimlich maneuver, should a bystander do a tracheostomy?
Answers:
I do not know anysubstance that inhibit Na+/K+ pump in the nephron.
But Na+/K+ 2 Cl- inhibitors like furosimide at the thick ascending limb( dampen pill ) cause more water to be excreted. Inhibitors like triamteride ( K+ sparing ) inhibits Na+/ K+ exchange at the collecting ducts. Both increase the concentration of solutes within the tubular fluids an cause diuresis.
Aminoacids are reabsorbed with sodium in the proximal tubules. Inhibition of Na+/K+ pump will increase intra cellular sodium and as a consequence can indirectly inhibit its absorption. Source(s): http://en.wikipedia.org/wiki/Diuretic
the Na/K pump has been call a pace maker of cellular respiration, accounting for 1/2 of all respiration within the body. (discussion of thyroid hormone effects on ATPase concentrations in cells found in "Foye's Principles of Medicinal Chemistry, 2nd edition, Chapter 26 by Nicolas Zenker).
"The bulk of adjectives transport in the kidney is due to the abundant supply of Na+,K+ - ATPase in the basolateral membranes of the renal epithelial cell and the separation of Na+ and K+ across the cell membrane." (Pharmacology text listed below)
You would expect Organic Acid and Organic Base transport (powered by the Sodium pump) to cease, and that alone would murder the patient.
I have not carefully studied the topic, I am freshly picking out what I have skimmed from a brief reading. Source(s): Goodman and Gilman's The Pharmacological Basis of Therapeutics, 11th edition, page 740-741. See chapter 28 written by Edwin K. Jackson, but before you do that read a little contained by chapter 1 regarding cell membrane and transport through membranes.
Related Questions: