Abdominal tumor step1 mcq?

A newborn child is noted to have a bulky abdominal tumor. CT scans reveal that the mass involves the right abdomen and retroperitoneum. The tumor is resected, revealing ganglion cell and primitive, small, round cells occasionally organized in rosettes, embedded surrounded by a fibrillary pink matrix. Special studies confirm the likely diagnosis. Which of the following features of this tumor is associated with a poorer prognosis?
A. Amplification of N-myc gene
B. Cellular aneuploidy
C. Diagnosis at birth
D. Numerous ganglion cells
E. Tumor spread into right kidney
Answers:
The correct answer is A.

Neuroblastoma is a childhood tumor of the sympathetic nerves, which most commonly arises along the paravertebral manacle or within the adrenal medulla. Neuroblastoma has two characteristic genetic marker: a 1p deletion and an N-myc translocation. N-myc is an oncogene that resides on chromosome 2p, and is amplified up to 300 times in neuroblastoma. Amplification of this gene is associated with a poorer prognosis.
The N-myc gene being amplified is NEVER a moral sign with cancers... especially neuroblastomas, but certainly abdominal common herd, too.

You didn't know this? Source(s): Basic college freshman histology course

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