What is surrounded by grapefruit that when taken beside some medication it can motivation a allergic reaction?
Answers:
A number of compounds in grapefruit block a secure enzyme, and this action increases the bioavailability of many drugs. Some of these compounds are naringin, bergamottin and dihydroxybergamottin. Source(s): http://en.wikipedia.org/wiki/Grapefruit#…
The main action of the aforementioned compounds in grapefruit liquid is the inhibition of the enzyme Cytochrome P450 in the intestinal wall.
I can personally atest to this after ending up within hospital in a coma after mixing grapefruit juice and a narcoleptic. Source(s): http://www.erowid.org/experiences/exp.ph…
I don't really have all the answers but it depends on the medicine, It is not agreed exactly what grapefruit juice contains that causes these drug interactions. Some researchers think that narningenin, DHB, or both are the compounds contained by grapefruit juice that may be responsible for the interaction.1,2,3 What we do know is that some drugs need certain inherent enzymes in the body to break them down so that medicine can be eliminated from the body. Grapefruit liquid interferes with one of these enzymes, CYP3A4. It may cause some medicine to build up surrounded by the body, leading to unwanted side effects. The amount of CYP3A4 found in a person will ebb and flow from person to person. People with complex amounts of the enzyme are affected when grapefruit juice is taken with prescription more often than people with lower amounts.
Not adjectives citrus juices contain narningenin or DHB. For this reason, citrus juices such as red juice have not been shown to affect this enzyme.2
The following is a partial document of medication that interacts with grapefruit juice in some relations.
atorvastatin (Lipitor)2
buspirone (Buspar)2
carbamazepine (Tegretol)2
cerivastatin (Baycol)2
cyclosporine (Sandimmune)1, 2, 3
diazepam (Valium)2
erythromycin (E-Mycin, Ery-Tab, E-base, E.E.S., Ery-Ped)
felodipine (Plendil)1, 2, 3, 4
lovastatin (Mevacor)2
methadone (Dolophine, Methadose )2
midazolam (Versed)1, 2, 4, 5
nifedipine (Adalat, Procardia )2, 3
nimodipine (Nimotop)2, 3
nisoldipine (Sular)1, 2, 3, 5
saquinavir (Fortovase, Invirase )3
sertraline (Zoloft)2
sildenafil (Viagra)2
simvastatin (Zocor)2
tacrolimus (Prograf)2
triazolam (Halcion)2
Perhaps the acidity of it?
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