Half duration? pharmachology?

im seeking for a good explanation about the half go of the pharmacos
explicity when are administred several times (accumulative).
i prefer a text or chapter book or a web page

txs
Answers:
http://en.wikipedia.org/wiki/Biological_…
goodman and gilman. tried and true.
half go like radioactivity, time it takes to eliminate from system 1/2 of the acme level, measured from that peak. Dosing is then figure based on this. it is affected by protein binding, GFR. Pen-G was initially dosed as a continuous infusion because of its short partly life. Source(s): med school, class of '79
I recommend Goodman & Gilman's Pharmacological Basis of Therapeutics 11th ed. p.1790

In simplest terms, it's the time that it take your substrate to fall to half of its initial amount.

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