Pharmacokinetics interview?
Im trying to do a past exam question and need some serve with this one 'The 2 compartment model for drugs us initially complicated but gradually becomes more simplified over time' Explain.
Thanks for any comfort
Answers:
Drugs which exhibit a slow equilibration with peripheral tissues, are best described with a two compartment model.
There are 2 phases. The Alpha or distribution phase and the Beta or post distribution (elimination phase)
This is the formula: .C = Ao e^-at + Bo e^-bt
It is adjectives that after some time, C will become equal to B as A is reduced to zero. Indeed depending upon the magnitude of a relative to b (always a >>b), A reduces progressively until it reach zero. This is when t becomes large and consequently the exponent -a t become negligible. Then the above equation will be reduced to C = Bo e^-bt. At this time the concentration between the vascular and extravascular spaces have reached a pseudoequilibrium phase. From consequently on the logC versus t relationship will be described by a straight line. This concept is the basis of 'curve striping' (also known as feathering or the method of residual) which is the adjectives method for identification of compartmental models.
It's complicated. If you have any questions only email me. Source(s): Pharmacist
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Thanks for any comfort
Answers:
Drugs which exhibit a slow equilibration with peripheral tissues, are best described with a two compartment model.
There are 2 phases. The Alpha or distribution phase and the Beta or post distribution (elimination phase)
This is the formula: .C = Ao e^-at + Bo e^-bt
It is adjectives that after some time, C will become equal to B as A is reduced to zero. Indeed depending upon the magnitude of a relative to b (always a >>b), A reduces progressively until it reach zero. This is when t becomes large and consequently the exponent -a t become negligible. Then the above equation will be reduced to C = Bo e^-bt. At this time the concentration between the vascular and extravascular spaces have reached a pseudoequilibrium phase. From consequently on the logC versus t relationship will be described by a straight line. This concept is the basis of 'curve striping' (also known as feathering or the method of residual) which is the adjectives method for identification of compartmental models.
It's complicated. If you have any questions only email me. Source(s): Pharmacist
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