Is amoxicillin a sulfa-based drug?

my typhoid medicine says not to take sulfa-based drugs, but I own a scrip for amoxicillin. is it a sulfa-based drug?
No it's not. Amoxicillin is derived from penicillamic acid. Source(s): Pharmacist
no. But to make sure talk to your doctor;

amoxicillin, Amoxil, Apo-Amoxi , DisperMox, Novamoxin , Nu-Amoxi , Trimox, Wymox

Func. class.: Antiinfective, antiulcer

Chem. class.: Aminopenicillin

Do not verbs:




Action: Interferes with cell wall replication of susceptible organisms; the cell wall, rendered osmotically unstable, swells and bursts from osmotic pressure; bactericidal, lysis mediated by bacterial cell wall autolysins

Uses: Treatment of skin, respiratory, GI, GU infections; otitis media, gonorrhea. For gram-positive cocci (Staphylococcus aureus, Streptococcus pyogenes, Streptococcus faecalis, Streptococcus pneumoniae), gram-negative cocci (Neisseria gonorrhoeae, Neisseria meningitidis), gram-positive bacilli (Corynebacterium diphtheriae, Listeria monocytogenes), gram-negative bacilli (Haemophilus influenzae, Escherichia coli, Proteus mirabilis, Salmonella); prophylaxis of bacterial endocarditis; contained by combination with other drugs used for treatment of Helicobacter pylori

Unlabeled uses: Lyme disease, anthrax treatment, and prophylaxis


Systemic infections

o Adult: PO 750 mg-1.75 g daily in divided doses q8h

o Child: PO 20-50 mg/kg/day surrounded by divided doses q8h

Renal disease

o Adult: PO CCr 10-30 ml/min 250-500 mg q12h; CCr <10 ml/min 250-500 mg q24h; do not use 875 mg strength if CCr <50 ml/min

Gonorrhea/urinary tract infections

o Adult: PO 3 g given with 1 g probenecid as a single dose; followed by tetracycline or erythromycin therapy

Chlamydia trachomatis

o Adult: PO 500 mg/tid × 1 wk

Bacterial endocarditis prophylaxis

o Adult: PO 2 g 1 hr prior to procedure

o Child: PO 50 mg/kg/hr 1 hr prior to procedure; max 2 g

Helicobacter pylori

o Adult: PO 1000 mg bid, given with lansoprazole 30 mg bid, clarithromycin 500 mg bid × 2 wk or 1000 mg bid given beside omeprazole 20 mg bid, clarithromycin 500 mg bid × 2 wk, or 1000 mg tid given with lansoprazole 30 mg tid × 2 wk

Available forms: Caps 250, 500 mg; chew tabs 125, 200, 250, 400 mg; tabs 500, 875 mg; susp pediatric drops 50 mg/ml; susp 125, 200, 250, 400 mg/5 ml


CNS: Headache, seizure

GI: Nausea, vomiting, diarrhea, increased AST, ALT, abdominal pain, glossitis, colitis, pseudomembranous colitis

HEMA: Anemia, increased bleeding time, bone marrow depression, granulocytopenia

INTEG: Urticaria, rash

SYST: Anaphylaxis, respiratory distress, serum sickness, Stevens-Johnson syndrome

Contraindications: Hypersensitivity to penicillins

Precautions: Pregnancy (B), lactation, hypersensitivity to cephalosporins, neonates, severe renal disease, acute lymphocytic leukemia


PO: Peak 2 hr, duration 6-8 hr; half-life 1-1 1/3 hr, metabolized in liver, excreted surrounded by urine, crosses placenta, enters breast milk


Increase: amoxicillin level—probenecid

Increase: anticoagulant action—warfarin

Increase: methotrexate levels—methotrexate

Decrease: effectiveness of oral contraceptives


o Do not use acidophilus with antiinfectives; separate by several hours

Decrease: absorption—khat; separate by 2 hr

Drug/Lab Test

False positive: Urine glucose, urine protein, direct Coombs' interview



o I&O ratio; report hematuria, oliguria, since penicillin in high doses is nephrotoxic

o Any patient near a compromised renal system, since drug is excreted slowly in poor renal system function; toxicity may occur rapidly

o Hepatic studies: AST, ALT

o Blood studies: WBC, RBC, Hgb and Hct, bleeding time

o Renal studies: urinalysis, protein, blood, BUN, creatinine

o C&S earlier drug therapy; drug may be given as soon as culture is taken

o Bowel pattern before, during treatment; diarrhea, cramping, blood contained by stools, report to prescriber; pseudomembranous colitis may occur

o Skin eruptions after administration of penicillin to 1 wk after discontinuing drug

o Respiratory status: rate, character, wheezing, tightness within the chest

o Anaphylaxis: rash, itching, dyspnea, facial/laryngeal edema


PO route

o Shake suspension well before respectively dose; may be used alone or mixed in drinks; use immediately; discard unused portion of susp after 14 days

o Give around the clock, caps may be empty and mixed with liquids if needed


o Adrenaline, suction, tracheostomy set, endotracheal intubation equipment on unit

o Adequate intake of fluids (2 L) during diarrhea episodes

o Scratch testing to assess allergy after securing order from prescriber; usually done when penicillin is only drug of choice

o Storage in tight container; after reconstituting, oral suspension chilled for 14 days


o Therapeutic response: absence of infection; prevention of endocarditis, resolution of ulcer symptoms

Teach patient/family:

o That caps ma Source(s): Mosby's

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