Why are toxicity studies for potential drug candidate typically conducted on hepatocyte cultures?
Answers:
Because hepatocytes are thought to be a good model for liver toxicity.
because drugs are principally metabolized by hepatocytes, and by conducting a hepatocyte culture, it will determine the level of toxicity of certain drugs
Most medications are cleared primarily by the liver or kidneys. Hepatocyte cultures are relatively easy to grow and maintain, and to method their functionality.
Kidneys are easier to replace than livers. Ditto with supporting the function of failing kidneys vs livers. Here again hepatocytes are a better model, if you're going to have an issue with your med, you'd fairly it be renal than hepatic. Source(s): RN
Drug Safety and Pharmacovigilance professional
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