Serotonin binds to the chemoreceptor zone contained by the nouns postrema to induce vomitting?
i'm not a doctor or medical student. i'm in high school. i read this on wikipedia. im confused give or take a few something:
do SSRIs (serotonin reuptake inhibitors) and vitamin B6 (required for the conversion of the amino acid tryptophan to serotonin) cause nausea?
B6 is actually prescribed to prevent nausea and morning sickness.. it seem contradictory.
Answers:
So while it is true that serotonin (5HT) plays a role in nausea/vomiting, there are other complex mechanisms at play as powerfully. There are many types of 5HT receptors in the brain, and it appears that the 5HT-3 is the one involved in nausea. Typically, SSRI's do not raison d`¨ētre nausea, although in some patients they do. This is biological variation. The SSRI's definitely increase the level of synaptic 5HT, but depending on dose, frequency, duration, and the presence of other factors, may or may not cause nausea. Now, for B6, this is a co-factor that is used by adjectives decarboxylase enzymes, including aromatic amino acid decarboxylase that's used to convert 5-hydroxytyrptophan to 5HT. It does not cause nausea, by itself. Similarly, tryptophan or 5-hydroxytryptophan (both precursors for 5HT) do not cause nausea. So not everything that make 5HT or increases 5HT will cause nausea.
You seem to be pretty knowledgeable for a dignified school student. I didn't learn about this stuff until 2nd or 3rd year of college. Good luck to you, and I hope my answer wasn't too sour the mark.
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do SSRIs (serotonin reuptake inhibitors) and vitamin B6 (required for the conversion of the amino acid tryptophan to serotonin) cause nausea?
B6 is actually prescribed to prevent nausea and morning sickness.. it seem contradictory.
Answers:
So while it is true that serotonin (5HT) plays a role in nausea/vomiting, there are other complex mechanisms at play as powerfully. There are many types of 5HT receptors in the brain, and it appears that the 5HT-3 is the one involved in nausea. Typically, SSRI's do not raison d`¨ētre nausea, although in some patients they do. This is biological variation. The SSRI's definitely increase the level of synaptic 5HT, but depending on dose, frequency, duration, and the presence of other factors, may or may not cause nausea. Now, for B6, this is a co-factor that is used by adjectives decarboxylase enzymes, including aromatic amino acid decarboxylase that's used to convert 5-hydroxytyrptophan to 5HT. It does not cause nausea, by itself. Similarly, tryptophan or 5-hydroxytryptophan (both precursors for 5HT) do not cause nausea. So not everything that make 5HT or increases 5HT will cause nausea.
You seem to be pretty knowledgeable for a dignified school student. I didn't learn about this stuff until 2nd or 3rd year of college. Good luck to you, and I hope my answer wasn't too sour the mark.
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