Significance of p50 of haemoglobin?
what does it mean? i know that at this pressure, haemoglobin is 50% saturated. is there more to that? also, i know that near increased 2,3-DPG, the curve is shifted to the right, and so p50 is increased, which means it is 50% saturated at a higher PO2.. so? does it indicate the uptake of O2 in the lungs is diminished?
also, a curve shifted to the right means increased release in the tissues ae? or am i wrong?
HELP :D
Answers:
You can ruminate of it this way:
The haemoglobin p50, as you stated, is the partial pressure of oxygen (pO2) at which 50% of haemoglobin is saturated. That is the strict definition. To understand why that's exalted, we have to look at how/when the p50 changes, and its consequences.
When the p50 is shifted to the right, it takes a sophisticated pO2 to saturate 50% of haemoglobin. But an equally valid way of thinking about this is that, at like pO2, LESS haemoglobin is saturated--meaning that haemoglobin grips oxygen less tightly. That's important when you want oxygen going into tissues that need it, similar to muscles during exercise, so you want haemoglobin to be able to give up that oxygen easily and immediately.
Various things shift p50 to the right, including 2,3-BPG, acidity, carbon dioxide, and increased temperature. What they all hold in common is that they increase when you exercise and/or when tissues have increased oxygen requirements.
What around in the lungs? Well, the pO2 is always so high within the lungs (...unless you stop breathing, of course) that haemoglobin always gets 100% saturated within the lungs, before the heart pumps it out to the rest of your body. The shifting of the p50 only comes into play in the divergent tissues (like muscles) to enable the haemoglobin to unload oxygen faster when it's needed. Source(s): med school
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also, a curve shifted to the right means increased release in the tissues ae? or am i wrong?
HELP :D
Answers:
You can ruminate of it this way:
The haemoglobin p50, as you stated, is the partial pressure of oxygen (pO2) at which 50% of haemoglobin is saturated. That is the strict definition. To understand why that's exalted, we have to look at how/when the p50 changes, and its consequences.
When the p50 is shifted to the right, it takes a sophisticated pO2 to saturate 50% of haemoglobin. But an equally valid way of thinking about this is that, at like pO2, LESS haemoglobin is saturated--meaning that haemoglobin grips oxygen less tightly. That's important when you want oxygen going into tissues that need it, similar to muscles during exercise, so you want haemoglobin to be able to give up that oxygen easily and immediately.
Various things shift p50 to the right, including 2,3-BPG, acidity, carbon dioxide, and increased temperature. What they all hold in common is that they increase when you exercise and/or when tissues have increased oxygen requirements.
What around in the lungs? Well, the pO2 is always so high within the lungs (...unless you stop breathing, of course) that haemoglobin always gets 100% saturated within the lungs, before the heart pumps it out to the rest of your body. The shifting of the p50 only comes into play in the divergent tissues (like muscles) to enable the haemoglobin to unload oxygen faster when it's needed. Source(s): med school
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