Is near any open-handed of lesser amount or robustness problem where on earth you stipulation more pills to quality any effect?

I'm not talking like building a resistance to medication or drugs, I'm talking if someone else alike build physically takes 100mg of something they've never taken before, and I take 100 mg or something I've never taken until that time, why do I not feel it and he does?
I want to know if there's like some deficiency or something to be exact preventing me from feeling anything from this item, and why my friend does.
Answers:
Yes, there is. Most drugs are metabolized (inactivated, though few drug -called prodrug- is activated) in liver. Its possible for someone have liver metabolism faster than average people. They surely need larger dose of drug to achieve matching effect.

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