My son toxicology report said his blood cocaine stratum be 0.02mg/L. Is it a glorious height?
he was killed in a sports car accident I need to know if that was a giant level and how soon before his accident did he use the drug and his benzoylecgonine rank was 0.54mg/L
Answers:
All of the above information is correct and is what is listed in the DIH (Drug Information Handbook), the PDR (Physician's Desk Reference) as capably as the TIH (Toxicology Information Handbook).
I am thinking that what you may really want to know here, is not so much the pharmacology and the pharmicokinetics of cocaine, but instead are curious to know if your son has a problem or dependency on cocaine.
The answer is, that if he popped a positive fo cocaine at all on a blood or serum drug screen, afterwards he probably does have an issue. Cocaine metabolizes out of the blood stream extremely fast, so for an infrequent user, the probability of them showing a positive result at all for cocaine would be intensely low.
Because he did test positive (and 0.02mg/L is not extremely high, but is moderate), indicates that he is most likely using every daylight, which is why even though the drug metabolizes quickly, he is testing positive, because just as his body is breaking down and eliminate the drug, he is putting more in there and is thus maintaining a constant even. Source(s): Phd Toxicology
First, my condolences on the death of your son.
If your son died immeditely, then a blood cocaine concentration of .02mg/L is not considered high, but as also pointed out by LabRat, cocaine is fast metabolized which means his blood level could have be higher prior to the crash. I agree. However, if he passed after several hours of medical treatment, his cocaine concentration may have been much superior at the time of the crash.
Despite many laws against drug use and driving and public awareness campaigns just about not using drugs and driving, there is very little scientific background that acute cocaine impairs driving (to the degree that alcohol or other drugs may). In fact, the National Highway Traffic Safety Administration, surrounded by a relatively recent review on Drugs and Driving, concluded that stimulants are not clearly causal factors in impair driving and that some stimulants may actually improve driving. However, those studies are with relatively low doses of stimulants and do not consider crashes, deduction or higher doses all of which have psychological and physiological effects that would impair skills necessary for safe motor vehicle operation. There are so many factor to consider in determining causality, it would be impossible to say without much more background.
So, yes, your son was under the influence of cocaine but without a large amount more information, it would be speculative to conclude that his cocaine use was a significant factor in his brutal crash. I hope that helps to answer your question. Source(s): I am a forensic psychopharmacologist and work with multiple state agencies on lethal car crashes involving alcohol and other drugs.
Interpretation of Blood Concentrations: The presence of cocaine at a given blood concentration cannot usually be associated with a degree of impairment or a specific effect for a given individual lacking additional information. This is due to many factors, including individual level of tolerance to the drug and artifactual changes in cocaine concentrations on storage. There is a large overlap between medical, toxic and lethal cocaine concentrations and adverse reactions have be reported after prolonged use even with no measurable parent drug in the blood. Typical concentrations in maltreat range from 0-1mg/L, however, concentrations up to 5mg/L and higher are survivable in tolerant individuals. After single doses of cocaine, plasma concentration typically average 0.2-0.4 mg/L. Repeated doses of cocaine may result contained by concentrations greater than 0.75 mg/L.
Following intranasal administration of 106 mg, peak plasma concentrations of cocaine averaged 0.22 mg/L at 30 minutes, while benzoylecgonine concentrations averaged 0.61 mg/L at 3 hours. Oral administration of 140 mg/70 kg cocaine resulted contained by peak plasma concentrations averaging 0.21 mg/L of cocaine at 1 hour. Single 32 mg intravenous doses of cocaine produced an average peak plasma concentration of 0.31 mg/L of cocaine within 5 minutes. Smoking 50 mg of cocaine platform resulted in peak plasma cocaine concentrations averaging 0.23 mg/L at ~ 45 minutes and 0.15 mg/L of benzoylecgonine at 1.5 hours. Source(s): http://www.nhtsa.dot.gov/people/injury/r…
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Answers:
All of the above information is correct and is what is listed in the DIH (Drug Information Handbook), the PDR (Physician's Desk Reference) as capably as the TIH (Toxicology Information Handbook).
I am thinking that what you may really want to know here, is not so much the pharmacology and the pharmicokinetics of cocaine, but instead are curious to know if your son has a problem or dependency on cocaine.
The answer is, that if he popped a positive fo cocaine at all on a blood or serum drug screen, afterwards he probably does have an issue. Cocaine metabolizes out of the blood stream extremely fast, so for an infrequent user, the probability of them showing a positive result at all for cocaine would be intensely low.
Because he did test positive (and 0.02mg/L is not extremely high, but is moderate), indicates that he is most likely using every daylight, which is why even though the drug metabolizes quickly, he is testing positive, because just as his body is breaking down and eliminate the drug, he is putting more in there and is thus maintaining a constant even. Source(s): Phd Toxicology
First, my condolences on the death of your son.
If your son died immeditely, then a blood cocaine concentration of .02mg/L is not considered high, but as also pointed out by LabRat, cocaine is fast metabolized which means his blood level could have be higher prior to the crash. I agree. However, if he passed after several hours of medical treatment, his cocaine concentration may have been much superior at the time of the crash.
Despite many laws against drug use and driving and public awareness campaigns just about not using drugs and driving, there is very little scientific background that acute cocaine impairs driving (to the degree that alcohol or other drugs may). In fact, the National Highway Traffic Safety Administration, surrounded by a relatively recent review on Drugs and Driving, concluded that stimulants are not clearly causal factors in impair driving and that some stimulants may actually improve driving. However, those studies are with relatively low doses of stimulants and do not consider crashes, deduction or higher doses all of which have psychological and physiological effects that would impair skills necessary for safe motor vehicle operation. There are so many factor to consider in determining causality, it would be impossible to say without much more background.
So, yes, your son was under the influence of cocaine but without a large amount more information, it would be speculative to conclude that his cocaine use was a significant factor in his brutal crash. I hope that helps to answer your question. Source(s): I am a forensic psychopharmacologist and work with multiple state agencies on lethal car crashes involving alcohol and other drugs.
Interpretation of Blood Concentrations: The presence of cocaine at a given blood concentration cannot usually be associated with a degree of impairment or a specific effect for a given individual lacking additional information. This is due to many factors, including individual level of tolerance to the drug and artifactual changes in cocaine concentrations on storage. There is a large overlap between medical, toxic and lethal cocaine concentrations and adverse reactions have be reported after prolonged use even with no measurable parent drug in the blood. Typical concentrations in maltreat range from 0-1mg/L, however, concentrations up to 5mg/L and higher are survivable in tolerant individuals. After single doses of cocaine, plasma concentration typically average 0.2-0.4 mg/L. Repeated doses of cocaine may result contained by concentrations greater than 0.75 mg/L.
Following intranasal administration of 106 mg, peak plasma concentrations of cocaine averaged 0.22 mg/L at 30 minutes, while benzoylecgonine concentrations averaged 0.61 mg/L at 3 hours. Oral administration of 140 mg/70 kg cocaine resulted contained by peak plasma concentrations averaging 0.21 mg/L of cocaine at 1 hour. Single 32 mg intravenous doses of cocaine produced an average peak plasma concentration of 0.31 mg/L of cocaine within 5 minutes. Smoking 50 mg of cocaine platform resulted in peak plasma cocaine concentrations averaging 0.23 mg/L at ~ 45 minutes and 0.15 mg/L of benzoylecgonine at 1.5 hours. Source(s): http://www.nhtsa.dot.gov/people/injury/r…
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