Discuss what would arise to muscular contraction contained by these situations?
You have been exposed to a chemical that destoys acetylcholinesterase.
You have basically been shot by a dart gun. Unfortunately, the tip of the dart was dipped in curare, which is a poison that binds to ACh receptors. What is going to occur to you?
Answers:
It is correct that, without artificial ventilation, you would die either mode. But exactly what happens to the muscles would be slightly different.
If you were poisoned with a chemical that destroys acetylcholinesterase, the ACh would build up within the neuromuscular junctions and hyperpolarise the muscle cells. This form of paralysis is characterised by initial violent twitching and contraction of the muscles (tetany) followed by flaccid (loose) paralysis.
If you be poisoned with curare, the neuromuscular junctions would be blocked, but not hyperpolarised. You would progress directly to flaccid paralysis.
You are likely going to die because curare is the toxin present on poison dart frogs. The binding of the AChR is going to prevent Ach from binding which will contained by turn eliminate the ability of the muscles to contract. This will also affect the diaphragm which will cause you to stop breathing resulting contained by asphyxiation.
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You have basically been shot by a dart gun. Unfortunately, the tip of the dart was dipped in curare, which is a poison that binds to ACh receptors. What is going to occur to you?
Answers:
It is correct that, without artificial ventilation, you would die either mode. But exactly what happens to the muscles would be slightly different.
If you were poisoned with a chemical that destroys acetylcholinesterase, the ACh would build up within the neuromuscular junctions and hyperpolarise the muscle cells. This form of paralysis is characterised by initial violent twitching and contraction of the muscles (tetany) followed by flaccid (loose) paralysis.
If you be poisoned with curare, the neuromuscular junctions would be blocked, but not hyperpolarised. You would progress directly to flaccid paralysis.
You are likely going to die because curare is the toxin present on poison dart frogs. The binding of the AChR is going to prevent Ach from binding which will contained by turn eliminate the ability of the muscles to contract. This will also affect the diaphragm which will cause you to stop breathing resulting contained by asphyxiation.
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