Why is serum parathyroid hormone elevated within Rickets?
As title.
Answers:
The answer is not as clear cut as even the busiest answer would suggest.
PTH is secreted when the serum calcium is low.
PTH triggers release of calcium from the bone (which make the rickets worse) and an increase in adsorption from the gut (partly via vit. D).
The PTH is intended to protect all the other bodily functions that depend on calcium (like muscles and heart) at the expense of bone. So the high PTH is module of the disease process. NOT a amelioration repair process
Thank you for the question.
Indeed, the first responder is correct, but to strengthen that response, the PTH is elevated because of the hormonal unenthusiastic feedback loop between vitamin D levels and PTH.
In Rickets (or osteomalacia in adults), the underlying vitamin D deficiency is detected by the cell of the parathyroid gland, which attempt to compensate for this deficiency by secreting PTH, which goes into effect as described above.
ADDENDUM:
Thank you for the other question.
Alkaline phosphatase (ALP) is an enzyme that is involved in bone turnover (among other things), specifically bone loss or destruction.
An elevated ALP can result from the poor mineralization/loss of bone. Further, within the secondary hyperparathyroidism (whether it is from Rickets or any other cause), the elevated PTH can also be deleterious to bone, because it is known for paradoxically cause destruction of bone (far beyond its intended effect of short-term bone resorption to increase serum calcium and enhanced viatmin D synthesis), thus raising the serum ALP. However, this effect occurs only at severely high-ranking and sustained levels of PTH. Thus, unfortunately, PTH is both a friend (short-term) and foe (long-term) in calcium/vitamin D homeostasis. Source(s): My remote medical training.
Because Rickets are caused by an inadequate supply of vitamin D and vitamin D deficiency cause a low calcium and phosphate, which can cause secondary hyperparathyroidism.
The parathyroid hormone helps to control calcium and phosphorus level in your body and the parathyroid hormone release is triggered when the levels of calcium in the blood leak too low.
If there are low levels of calcium in the blood, the parathyroid glands are lastingly being stimulated by the body to try to raise the calcium level to compensate. As a result, the parathyroid glands enlarge and their output of parathyroid hormone increases. The raise levels of parathyroid hormone are appropriate due to the low blood calcium levels. Source(s): Cardiac Nurse
Parathyroid hormone (PTH) increases the activity of 1-α-hydroxylase enzyme, which converts 25-hydroxycholecalciferol to 1,25-dihydroxycholecalciferol, the active form of vitamin D. Source(s): http://en.wikipedia.org/wiki/Parathyroid…
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Answers:
The answer is not as clear cut as even the busiest answer would suggest.
PTH is secreted when the serum calcium is low.
PTH triggers release of calcium from the bone (which make the rickets worse) and an increase in adsorption from the gut (partly via vit. D).
The PTH is intended to protect all the other bodily functions that depend on calcium (like muscles and heart) at the expense of bone. So the high PTH is module of the disease process. NOT a amelioration repair process
Thank you for the question.
Indeed, the first responder is correct, but to strengthen that response, the PTH is elevated because of the hormonal unenthusiastic feedback loop between vitamin D levels and PTH.
In Rickets (or osteomalacia in adults), the underlying vitamin D deficiency is detected by the cell of the parathyroid gland, which attempt to compensate for this deficiency by secreting PTH, which goes into effect as described above.
ADDENDUM:
Thank you for the other question.
Alkaline phosphatase (ALP) is an enzyme that is involved in bone turnover (among other things), specifically bone loss or destruction.
An elevated ALP can result from the poor mineralization/loss of bone. Further, within the secondary hyperparathyroidism (whether it is from Rickets or any other cause), the elevated PTH can also be deleterious to bone, because it is known for paradoxically cause destruction of bone (far beyond its intended effect of short-term bone resorption to increase serum calcium and enhanced viatmin D synthesis), thus raising the serum ALP. However, this effect occurs only at severely high-ranking and sustained levels of PTH. Thus, unfortunately, PTH is both a friend (short-term) and foe (long-term) in calcium/vitamin D homeostasis. Source(s): My remote medical training.
Because Rickets are caused by an inadequate supply of vitamin D and vitamin D deficiency cause a low calcium and phosphate, which can cause secondary hyperparathyroidism.
The parathyroid hormone helps to control calcium and phosphorus level in your body and the parathyroid hormone release is triggered when the levels of calcium in the blood leak too low.
If there are low levels of calcium in the blood, the parathyroid glands are lastingly being stimulated by the body to try to raise the calcium level to compensate. As a result, the parathyroid glands enlarge and their output of parathyroid hormone increases. The raise levels of parathyroid hormone are appropriate due to the low blood calcium levels. Source(s): Cardiac Nurse
Parathyroid hormone (PTH) increases the activity of 1-α-hydroxylase enzyme, which converts 25-hydroxycholecalciferol to 1,25-dihydroxycholecalciferol, the active form of vitamin D. Source(s): http://en.wikipedia.org/wiki/Parathyroid…
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