Combinatorial chemistry - please give support to me out beside this sudden cross-question something like possible synthesis?
"How many compounds would there be in a combinatorial library of ester compounds made from every isomer of monofluorobenzoic acerbic and every possible alkyl alcohol with 4 or less carbon atoms?"
So, to make an ester we combine a carboxylic bitter with an alcohol (clearly, as hinted in the question). I try writing out the possible isomers for each description and I attain lost somewhere here. How many isomers of each reactant are there and even afterwards, what do I do with these numbers to find the number of ester compounds produced?
possible answers:
a) 11
b) 12
c) 21
d) 24
please explain how to do this. I will really, really appreciate it.
Answers:
Hmm...tough question. This is how I would approach it.
First, figure out adjectives the possible carboxylic acids that you can make.
It maybe would help to draw the structure of benzoic acerbic and place a flourine group on the benzene ring, and see how many ways you can place the groups on different positions. These are the different carboxylic acids that I made (I'm going to label them so it will be easier later on to solve the problem), a total of 3 carb. acids:
2-flouro benzoic sharp (A)
3-fluoro benzoic acid (B)
4-fluoro benzoic acid (C)
Now figure out adjectives the possible alcohols that you can make containing 4 or fewer carbons. These are the ones I found (again, I'm labeling them to be easier later on), a total of 7 alcohols:
Methanol (D)
Ethanol (E)
1-propanol (F)
2-propanol (G)
1-butanol (H)
2-butanol (I)
2-methyl 2-propanol (J)
Now, the different ways you can spawn an ester would be to combine:
A and D
A and E
A and F
A and G
A and H
A and I
A and J
B and D
B and E
B and F
B and G
B and H
B and I
B and J
C and D
C and E
C and F
C and G
C and H
C and I
C and J
After totalling up all the possible esters, I get 21 possible esters, which would be answer C. That's how I would best approach this problem.
Hope this helps! Source(s): UW pharmacy student
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So, to make an ester we combine a carboxylic bitter with an alcohol (clearly, as hinted in the question). I try writing out the possible isomers for each description and I attain lost somewhere here. How many isomers of each reactant are there and even afterwards, what do I do with these numbers to find the number of ester compounds produced?
possible answers:
a) 11
b) 12
c) 21
d) 24
please explain how to do this. I will really, really appreciate it.
Answers:
Hmm...tough question. This is how I would approach it.
First, figure out adjectives the possible carboxylic acids that you can make.
It maybe would help to draw the structure of benzoic acerbic and place a flourine group on the benzene ring, and see how many ways you can place the groups on different positions. These are the different carboxylic acids that I made (I'm going to label them so it will be easier later on to solve the problem), a total of 3 carb. acids:
2-flouro benzoic sharp (A)
3-fluoro benzoic acid (B)
4-fluoro benzoic acid (C)
Now figure out adjectives the possible alcohols that you can make containing 4 or fewer carbons. These are the ones I found (again, I'm labeling them to be easier later on), a total of 7 alcohols:
Methanol (D)
Ethanol (E)
1-propanol (F)
2-propanol (G)
1-butanol (H)
2-butanol (I)
2-methyl 2-propanol (J)
Now, the different ways you can spawn an ester would be to combine:
A and D
A and E
A and F
A and G
A and H
A and I
A and J
B and D
B and E
B and F
B and G
B and H
B and I
B and J
C and D
C and E
C and F
C and G
C and H
C and I
C and J
After totalling up all the possible esters, I get 21 possible esters, which would be answer C. That's how I would best approach this problem.
Hope this helps! Source(s): UW pharmacy student
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