Any drug interaction near eptoin?
Answers:
It has significant interactions:
Drug Interactions:
There are many drugs which may increase or decrease phenytoin level or which Phenytoin may affect. The most commonly occurring drug interactions are listed below:
1.
Drugs which may increase Phenytoin serum levels include: chloramphenicol, dicumarol, disulfiram, tolbutamide, isoniazid, phenylbutazone, acute alcohol intake, salicylates, chlordiazepoxide, phenothiazines, diazepam, estrogens, ethosuximide, halothane, methylphenidate, sulfonamides, cimetidine, trazodone.
2.
Drugs which may decrease Phenytoin level include: carbamazepine, chronic alcohol abuse, reserpine, molindone hydrochloride which contains calcium ions interferes with the absorption of phenytoin. Ingestion times of Phenytoin and antacid preparations containing calcium should be staggered surrounded by patients with low serum Phenytoin levels to prevent absorption problems.
3.
Drugs which may any increase or decrease phenytoin serum levels include: phenobarbital, valproic acid, and sodium valproate. Similarly, the effect of Phenytoin on phenobarbital, valproic sour and sodium valproate serum levels is unpredictable.
4.
Although not a true drug interaction, tricyclic antidepressants may precipitate seizures in susceptible patients and Phenytoin dosage may call for to be adjusted.
5.
Drugs whose efficacy is impaired by Phenytoin include: corticosteroids, coumarin anticoagulants, oral contraceptives, quinidine, vitamin D, digitoxin, rifampin, doxycycline, estrogens, furosemide.
Talk to your doctor/chemist/pharmacist Source(s): http://www.drugs.com/pro/phenytoin.html
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