Could human endorphins be the subsequent drugs?
When people use recreational drugs, they basically take within chemicals that alter the neurotransmitters in their brain, making them feel a certain approach. Human hormones, like endorphins ('happy hormones') do a similar thing. We already make hormones to use surrounded by therapy for infertility and other conditions. So, why don't we use endorphins or similar hormones in the same means of access as drugs, synthesising them outside the body and introducing them into the bloodstream?
I'd like a fairly detailed answer if you can, from a doctor or someone with a medical situation. Thanks!
Answers:
no its easyer and cheaper to produse a drug that works in your brain to produse extra endorphins
endorphins are a unstable substace and complicated to produse
normal drug do a better job at making it inside your body
Endorphins are only active surrounded by the central nervous system, behind the blood brain screen. They are not active when ingested, or injected into the blood - in the stomach, as peptides they would be digested almost instantly. In the bloodstream, they could not get to the site at which they are busy due to the blood brain barrier, and would eventually be degraded.
In order for an endorphin to have an effect, it would own to be injected between the bones of the spinal column directly into the intrathecal space of the spine, a procedure which carries major risks.
Well Opiates (narcotics) mimic endorphins. Endorphins are often called opioid peptides. Both endorphins and opiates produce analgesia (pain control). It is because of endorphins that people can be painless, own energy, and feel empowered after a severe injury. This is a defense works so that if you were to have several bones broken you could still continue to m¨ºl¨¦e an enemy without the extreme pain.
However endorphins do not inflict the same type of dopamine release as opiates do. Dopamine is a "feel good" chemical and the that is released by addictive drugs contained by far greater amounts than the human brain could naturally release. It is partly because of the lack of dopamine interaction that would never allow endorphins to be abused.
As another soul said, endorphins can not pass through the blood brain barrier. So taking the natural drug will not enter the brain or produce any results.
It took profusely of research to make L-dopa. L-dopa is chemically inactive but it can pass into the brain and turns into dopamine for the treatment of Parkinson's. But taking dopamine does zilch.
So we can synthesize hormones but for the most part, psychoactive chemicals will not be able to enter the brain.
Thus psychoactive pharmaceuticals exist to either increase or fade away a neurotransmitter often by tricking the brain into thinking that the drug is the same as the naturally occurring chemical.
It would be nice if you could a moment ago give people the 'raw' hormone or neurotransmitter because they work and are not addictive. But we can't.
And the brain is designed to be fairly equal. So when a entity takes Morphine (legally or not) the brain will respond to the drug on a physical and, over a long time, a genetic level to restore "order." So the brain think that all of the extra endorphins (which is really morphine) is an extreme so the brain desensitizes (to be simple) to the morphine and will begin to shut down its natural production of endorphins. So when a IV heroin user stops the drug, the withdrawal is in part due to the body person unable to adapt to the loss of the drug. In withdrawal from opiates folks will actually have extreme pain because of the loss of both the artificial drug and because endorphin production have been reduced. Source(s): I am a medical student with a specialist degree (Hons. BSc) within Pharmacology with a focus on psychopharmacology. I have interned under two psychiatrists, one neurologist, and at a Chemical Dependency Rehabilitation Centre. In mixing I have worked as a pharmacy assistant.
Yes, its very possible. It would be just like me smoking some weed, because it releases dopeamine. endorphins are what make you quality good after you have worked out, They could have some foul language potential.
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I'd like a fairly detailed answer if you can, from a doctor or someone with a medical situation. Thanks!
Answers:
no its easyer and cheaper to produse a drug that works in your brain to produse extra endorphins
endorphins are a unstable substace and complicated to produse
normal drug do a better job at making it inside your body
Endorphins are only active surrounded by the central nervous system, behind the blood brain screen. They are not active when ingested, or injected into the blood - in the stomach, as peptides they would be digested almost instantly. In the bloodstream, they could not get to the site at which they are busy due to the blood brain barrier, and would eventually be degraded.
In order for an endorphin to have an effect, it would own to be injected between the bones of the spinal column directly into the intrathecal space of the spine, a procedure which carries major risks.
Well Opiates (narcotics) mimic endorphins. Endorphins are often called opioid peptides. Both endorphins and opiates produce analgesia (pain control). It is because of endorphins that people can be painless, own energy, and feel empowered after a severe injury. This is a defense works so that if you were to have several bones broken you could still continue to m¨ºl¨¦e an enemy without the extreme pain.
However endorphins do not inflict the same type of dopamine release as opiates do. Dopamine is a "feel good" chemical and the that is released by addictive drugs contained by far greater amounts than the human brain could naturally release. It is partly because of the lack of dopamine interaction that would never allow endorphins to be abused.
As another soul said, endorphins can not pass through the blood brain barrier. So taking the natural drug will not enter the brain or produce any results.
It took profusely of research to make L-dopa. L-dopa is chemically inactive but it can pass into the brain and turns into dopamine for the treatment of Parkinson's. But taking dopamine does zilch.
So we can synthesize hormones but for the most part, psychoactive chemicals will not be able to enter the brain.
Thus psychoactive pharmaceuticals exist to either increase or fade away a neurotransmitter often by tricking the brain into thinking that the drug is the same as the naturally occurring chemical.
It would be nice if you could a moment ago give people the 'raw' hormone or neurotransmitter because they work and are not addictive. But we can't.
And the brain is designed to be fairly equal. So when a entity takes Morphine (legally or not) the brain will respond to the drug on a physical and, over a long time, a genetic level to restore "order." So the brain think that all of the extra endorphins (which is really morphine) is an extreme so the brain desensitizes (to be simple) to the morphine and will begin to shut down its natural production of endorphins. So when a IV heroin user stops the drug, the withdrawal is in part due to the body person unable to adapt to the loss of the drug. In withdrawal from opiates folks will actually have extreme pain because of the loss of both the artificial drug and because endorphin production have been reduced. Source(s): I am a medical student with a specialist degree (Hons. BSc) within Pharmacology with a focus on psychopharmacology. I have interned under two psychiatrists, one neurologist, and at a Chemical Dependency Rehabilitation Centre. In mixing I have worked as a pharmacy assistant.
Yes, its very possible. It would be just like me smoking some weed, because it releases dopeamine. endorphins are what make you quality good after you have worked out, They could have some foul language potential.
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