Could my Organs be Damaged from iron overdose?
I overdosed on iron vitamins about 4 years ago (21years old). I took about two bottles worth at one time, but I didn't even get sick. I feel weak and had the taste of iron surrounded by my mouth for about a week but that's it (never went to ER). I've had problems beside sharp chest pains and have even had a mini-stroke in second few years and have since developed a deep cough I can't get rid of. Could the iron still be contained by my body causing damage or could I have injury to my organs from this and not know it? I don't go to the doctor...only time I have within last four years was for tonsilitis and having a little one. Can the iron still be in my body even now or could my liver,heart, or other organs be damaged or is it okay because I didn't obtain sick from the overdose...so it wasn't that bad maybe?
Answers:
It's very possible - you should noticeably go to the doctor to get this checked out. The iron is probably not circulating in your system anymore, but as it is deposited and processed by the body, it can unambiguously cause severe damage, especially in your liver and lungs (a product call hemosiderin is produced, which deposits and causes damage). In any case, you should definitely jump see the doctor - iron overload (hemochromatosis) isn't something you can diagnose yourself; also the damage caused is permanent, but you may still be capable of limit the amount of damage done. The definite certainty is that it won't get better on its own (and liver/lung failure are pretty horrible conditions that you don't want to experience firsthand), so go achieve the correct treatment.
Iron is essential to nearly all known organisms. In cells, iron is roughly stored in the centre of metalloproteins, because "free" iron (which binds non-specifically to many cellular components) can catalyse production of toxic free radical. Iron deficiency can lead to iron deficiency anemia.
Iron distribution is heavily regulated within mammals, partly because iron has a high potential for biological toxicity[24]. Iron distribution is also regulated because various bacteria require iron, so restricting its availability to bacteria (generally by sequestering it inside cells) can help to prevent or define infections. This is probably the reason for the relatively low amounts of iron in mammalian milk. A major component of this regulation is the protein transferrin, which binds iron immersed from the duodenum and carries it in the blood to cells.[25]
Excessive iron can be toxic, because free ferrous iron react with peroxides to produce free radicals, which are highly reactive and can hurt DNA, proteins, lipids, and other cellular components. Thus, iron toxicity occurs when there is free iron in the cell, which mostly occurs when iron levels exceed the capacity of transferrin to bind the iron.
Iron uptake is tightly regulated by the human body, which have no regulated physiological means of excreting iron. Only small amounts of iron are lost daily due to mucosal and skin epithelial cell sloughing, so control of iron levels is mostly by regulating uptake.[33] However, voluminous amounts of ingested iron can cause excessive levels of iron in the blood because large iron levels can damage the cells of the gastrointestinal tract, preventing them from regulating iron digestion. The resulting high blood concentrations of iron damage cells within the heart, liver and elsewhere, which can cause serious problems, including long-term organ damage and even death.
Humans experience iron toxicity above 20 milligrams of iron for every kilogram of mass, and 60 milligrams per kilogram is a noxious dose.[34] Over-consumption of iron, often the result of children eating large quantity of ferrous sulfate tablets intended for adult consumption, is one of the most common toxicological causes of disappearance in children under six.[34] The DRI lists the Tolerable Upper Intake Level (UL) for adults as 45 mg/day. For children underneath fourteen years old the UL is 40 mg/day.
Regulation of iron uptake is impaired in some population as a result of a genetic defect that maps to the HLA-H gene region on chromosome 6. In these people, excessive iron intake can result within iron overload disorders, such as hemochromatosis. Many people have a genetic susceptibility to iron overload without realize it or being aware of a family history of the problem. For this reason, it is advise that people do not take iron supplements unless they suffer from iron deficiency and own consulted a doctor. Hemochromatosis is estimated to cause disease in between 0.3 and 0.8% of Caucasians.[35]
The medical management of iron toxicity is complex, and can include use of a specific chelating agent call deferoxamine to bind and expel excess iron from the body.[36] .
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Answers:
It's very possible - you should noticeably go to the doctor to get this checked out. The iron is probably not circulating in your system anymore, but as it is deposited and processed by the body, it can unambiguously cause severe damage, especially in your liver and lungs (a product call hemosiderin is produced, which deposits and causes damage). In any case, you should definitely jump see the doctor - iron overload (hemochromatosis) isn't something you can diagnose yourself; also the damage caused is permanent, but you may still be capable of limit the amount of damage done. The definite certainty is that it won't get better on its own (and liver/lung failure are pretty horrible conditions that you don't want to experience firsthand), so go achieve the correct treatment.
Iron is essential to nearly all known organisms. In cells, iron is roughly stored in the centre of metalloproteins, because "free" iron (which binds non-specifically to many cellular components) can catalyse production of toxic free radical. Iron deficiency can lead to iron deficiency anemia.
Iron distribution is heavily regulated within mammals, partly because iron has a high potential for biological toxicity[24]. Iron distribution is also regulated because various bacteria require iron, so restricting its availability to bacteria (generally by sequestering it inside cells) can help to prevent or define infections. This is probably the reason for the relatively low amounts of iron in mammalian milk. A major component of this regulation is the protein transferrin, which binds iron immersed from the duodenum and carries it in the blood to cells.[25]
Excessive iron can be toxic, because free ferrous iron react with peroxides to produce free radicals, which are highly reactive and can hurt DNA, proteins, lipids, and other cellular components. Thus, iron toxicity occurs when there is free iron in the cell, which mostly occurs when iron levels exceed the capacity of transferrin to bind the iron.
Iron uptake is tightly regulated by the human body, which have no regulated physiological means of excreting iron. Only small amounts of iron are lost daily due to mucosal and skin epithelial cell sloughing, so control of iron levels is mostly by regulating uptake.[33] However, voluminous amounts of ingested iron can cause excessive levels of iron in the blood because large iron levels can damage the cells of the gastrointestinal tract, preventing them from regulating iron digestion. The resulting high blood concentrations of iron damage cells within the heart, liver and elsewhere, which can cause serious problems, including long-term organ damage and even death.
Humans experience iron toxicity above 20 milligrams of iron for every kilogram of mass, and 60 milligrams per kilogram is a noxious dose.[34] Over-consumption of iron, often the result of children eating large quantity of ferrous sulfate tablets intended for adult consumption, is one of the most common toxicological causes of disappearance in children under six.[34] The DRI lists the Tolerable Upper Intake Level (UL) for adults as 45 mg/day. For children underneath fourteen years old the UL is 40 mg/day.
Regulation of iron uptake is impaired in some population as a result of a genetic defect that maps to the HLA-H gene region on chromosome 6. In these people, excessive iron intake can result within iron overload disorders, such as hemochromatosis. Many people have a genetic susceptibility to iron overload without realize it or being aware of a family history of the problem. For this reason, it is advise that people do not take iron supplements unless they suffer from iron deficiency and own consulted a doctor. Hemochromatosis is estimated to cause disease in between 0.3 and 0.8% of Caucasians.[35]
The medical management of iron toxicity is complex, and can include use of a specific chelating agent call deferoxamine to bind and expel excess iron from the body.[36] .
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