Commercial production of Mappia Foetida?
will anybody give any information on the above mentioned subject? I have to utilize the barren land within my village for giving sustainability to villagers. This plant extract is useful in anticancer medicine.
Answers:
United States Patent 5525609.
Alkaloids from Mappia foetida.
Abstract:The present invention relates to novel alkaloids from Mappia foetida, foetidine 1 and 2, having anticancer and antiviral properties. These alkaloids, soluble in marine, are present in all the parts of the plant, and are the precursors of camptothecin and of 9-methoxy-camptothecin, which are alkaloids known to enjoy pharmacodynamic properties but also to be insoluble in water. The particular sea solubility of the novel compounds make them particularly suitable for the treatment of the patients by the parenteral route, avoiding the use of toxic excipients or of unsuitable chemical derivatizations.
The resulting compounds be subjected to biological evaluation on human tumour cell lines (ovary, breast, colon, lung, resistant or not to other antitumourals, and the like) and on some virus strains. In fact, camptothecin, or better some of its derivatives, are known to have cytotoxic hum connected with the inhibition of DNA topoisomerases I and II.
The cytotoxicity, for example on a colon carcinoma cell line, is about 25 nM. The antiviral distraction of foetidine 1, even though related to the different resistance of the strains, takes place at concentrations ranging from 1 to 100 ng/ml. Foetidine 2, which differs from foetidine 1 for a methoxyl at the 9-position, act analogously. The herpes, cytomegalovirus and HIV viruses proved to be sensitive to the alkaloids of the invention.
The compounds of the invention can be incorporated in all kind of pharmaceutical formulations, but above all they can easily be administered by the parenteral route in aqueous solutions at a pH compatible beside blood, without causing problems such as precipitation or incompatibility. In the formulations, all the conventional pharmaceutical excipients can be used. The dosages of these fresh alkaloids can range from 0.5 mg to 200 mg per dose and therapeutical cycle. Doses of about 50 mgs proved to be preliminarily effective.
For more info:
www.freepatentsonline.com/5525609.html
www.ars-grin.gov/cgi-bin/npgs/html/tax… - Cached - www.ecplaza.net/search/0s1nf20sell/mappi… - Source(s): http://www.freepatentsonline.com/5525609…
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Answers:
United States Patent 5525609.
Alkaloids from Mappia foetida.
Abstract:The present invention relates to novel alkaloids from Mappia foetida, foetidine 1 and 2, having anticancer and antiviral properties. These alkaloids, soluble in marine, are present in all the parts of the plant, and are the precursors of camptothecin and of 9-methoxy-camptothecin, which are alkaloids known to enjoy pharmacodynamic properties but also to be insoluble in water. The particular sea solubility of the novel compounds make them particularly suitable for the treatment of the patients by the parenteral route, avoiding the use of toxic excipients or of unsuitable chemical derivatizations.
The resulting compounds be subjected to biological evaluation on human tumour cell lines (ovary, breast, colon, lung, resistant or not to other antitumourals, and the like) and on some virus strains. In fact, camptothecin, or better some of its derivatives, are known to have cytotoxic hum connected with the inhibition of DNA topoisomerases I and II.
The cytotoxicity, for example on a colon carcinoma cell line, is about 25 nM. The antiviral distraction of foetidine 1, even though related to the different resistance of the strains, takes place at concentrations ranging from 1 to 100 ng/ml. Foetidine 2, which differs from foetidine 1 for a methoxyl at the 9-position, act analogously. The herpes, cytomegalovirus and HIV viruses proved to be sensitive to the alkaloids of the invention.
The compounds of the invention can be incorporated in all kind of pharmaceutical formulations, but above all they can easily be administered by the parenteral route in aqueous solutions at a pH compatible beside blood, without causing problems such as precipitation or incompatibility. In the formulations, all the conventional pharmaceutical excipients can be used. The dosages of these fresh alkaloids can range from 0.5 mg to 200 mg per dose and therapeutical cycle. Doses of about 50 mgs proved to be preliminarily effective.
For more info:
www.freepatentsonline.com/5525609.html
www.ars-grin.gov/cgi-bin/npgs/html/tax… - Cached - www.ecplaza.net/search/0s1nf20sell/mappi… - Source(s): http://www.freepatentsonline.com/5525609…
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