Why doesn't Zetia come within dosages greater than 10mg?
Zetia, since it metabolizes in the digestive track and not the liver, is my best bet in lowering cholesterol, but my latest theory test show the cholesterol level is still high. I understand Zetia simply comes in 10mg dosages. Why is that? Wouldn't a higher dosage be preferable for someone like me who have side effects from statins contained in other cholesterol drugs. Please help! Thanks
Answers:
I try to answer in layman's permanent status.
For a drug to be marketed, it needs to go thru 5 stages contained by research.
At the last stage of research, humans are used to carried out experiments. This includes -
- what side effects will this medicine cause?
- what is the most appropriate efficient dosage
- adverse drug reaction
- half life and metabolism of the drug.
- does the drug modify any blood picture or any biodata
- safekeeping in pregnancy and paediatrics.
etc.
So, Zetia comes in 10mg is because at the research, they found out that 10mg is the safest dose that can achieve beneficial medical effects intended.
Ezetimibe is used together with lifestyle changes (diet, weight-loss, exercise) to exhaust the amount of cholesterol (a fat-like substance) and other fatty substances in the blood. It may be used alone or in combination with an HMG-CoA reductase inhibitor (statin). Ezetimibe is within a class of medications called cholesterol-lowering medications. It works by preventing the digestion of cholesterol in the intestine.
Ezetimibe is available as 10 mg tablets in most markets. A combination preparation ezetimibe/simvastatin, which combines ezetimibe beside a statin, is also available.
Ezetimibe is primarily metabolized in the liver and the small intestine via glucuronide conjugation with subsequent renal and biliary excretion. There has be great debate in the medical community on the use of ezetimibe in hypercholesterolemia. Source(s): http://en.wikipedia.org/wiki/Zetia
http://www.nlm.nih.gov/medlineplus/drugi…
http://www.medicinenet.com/ezetimibe/art…
My guess is that 11mg+ is harmful.
10mg is the dose that be deemed safe and effective through research. I know you said you receive adverse effects from statins, but Zetia can often be combined with statins to reduce the required dose of the statin. I'm not surprised that your cholesterol is still a touch high after the Zetia, because it is not as effective as statins at reducing LDL.
I am afraid this is the optimum dose of Ezetimibe. It is not a particularly powerful drug, and as you probably know, ideally it be designed as an add on to statins rather than a substitute,(except in those that can't tolerate statins.) It is also worth remembering that though it unambiguously reduces cholesterol somewhat it has not yet be shown to affect outcomes or prevent deaths.
Also as long ago as 1994 the 4S study showed that statins not only reduce cholesterol,they put aside lives.This is NOT only due to their lipid lowering effect but the fact that they change the moral fibre of pre-existing plaque,changing it from 'crispy' to 'rubbery'. This reduces the risk of it breaking off and effectively producing cholesterol emboli. This fact cannot be mimicked by any other drug and is definitely not a feature of Ezetimibe.
Even if it were possible to use a deeply small dose of a statin as well this would dramatically increase the statistics in your favour.
Pravastatin,no longer in as it has low potency,is often well tolerated contained by low doses. If this were tolerated when combined with Ezetimibe, it would improve your probability even if it did not dramatically lower your cholesterol. Source(s): GP for more years than I care to remember
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Answers:
I try to answer in layman's permanent status.
For a drug to be marketed, it needs to go thru 5 stages contained by research.
At the last stage of research, humans are used to carried out experiments. This includes -
- what side effects will this medicine cause?
- what is the most appropriate efficient dosage
- adverse drug reaction
- half life and metabolism of the drug.
- does the drug modify any blood picture or any biodata
- safekeeping in pregnancy and paediatrics.
etc.
So, Zetia comes in 10mg is because at the research, they found out that 10mg is the safest dose that can achieve beneficial medical effects intended.
Ezetimibe is used together with lifestyle changes (diet, weight-loss, exercise) to exhaust the amount of cholesterol (a fat-like substance) and other fatty substances in the blood. It may be used alone or in combination with an HMG-CoA reductase inhibitor (statin). Ezetimibe is within a class of medications called cholesterol-lowering medications. It works by preventing the digestion of cholesterol in the intestine.
Ezetimibe is available as 10 mg tablets in most markets. A combination preparation ezetimibe/simvastatin, which combines ezetimibe beside a statin, is also available.
Ezetimibe is primarily metabolized in the liver and the small intestine via glucuronide conjugation with subsequent renal and biliary excretion. There has be great debate in the medical community on the use of ezetimibe in hypercholesterolemia. Source(s): http://en.wikipedia.org/wiki/Zetia
http://www.nlm.nih.gov/medlineplus/drugi…
http://www.medicinenet.com/ezetimibe/art…
My guess is that 11mg+ is harmful.
10mg is the dose that be deemed safe and effective through research. I know you said you receive adverse effects from statins, but Zetia can often be combined with statins to reduce the required dose of the statin. I'm not surprised that your cholesterol is still a touch high after the Zetia, because it is not as effective as statins at reducing LDL.
I am afraid this is the optimum dose of Ezetimibe. It is not a particularly powerful drug, and as you probably know, ideally it be designed as an add on to statins rather than a substitute,(except in those that can't tolerate statins.) It is also worth remembering that though it unambiguously reduces cholesterol somewhat it has not yet be shown to affect outcomes or prevent deaths.
Also as long ago as 1994 the 4S study showed that statins not only reduce cholesterol,they put aside lives.This is NOT only due to their lipid lowering effect but the fact that they change the moral fibre of pre-existing plaque,changing it from 'crispy' to 'rubbery'. This reduces the risk of it breaking off and effectively producing cholesterol emboli. This fact cannot be mimicked by any other drug and is definitely not a feature of Ezetimibe.
Even if it were possible to use a deeply small dose of a statin as well this would dramatically increase the statistics in your favour.
Pravastatin,no longer in as it has low potency,is often well tolerated contained by low doses. If this were tolerated when combined with Ezetimibe, it would improve your probability even if it did not dramatically lower your cholesterol. Source(s): GP for more years than I care to remember
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