Relationship between paCO2 and C02 content from serum chemistry panel?
My professor went over these last week, and I was simply checking to get more info about them. Specifically though, I want to know how they are related. I'll explain to you what I do know already.
For the paC02 from arterial blood gases, I know the normal value 35-45 mmHg. I take to mean if it's above that value it's considered acidotic and below alkalotic. The value comes from the dissolved C02 in the plasma solely.
For C02 content of serum chemistry panel, the normal range is 23.2-27.2 mEq/L. It comes from the dissolve CO2 in plasma and the bicarbonate within the plasma.
***Make sure I'm correct on this: If the C02 content (from chem panel) goes up, then the amount of bicarbonate has increased and if decrease C02 content..then bicarbonate decrease. Is that correct and necessarily true all the time?
And for the relationship of paC02 and bicarbonate....it a moment ago depends on what is happening: eg) The amount of bicarbonate could be alkalotic to deal with an acidotic amount of paC02 to correct the pH (correction of resp acidosis or corrected metabolic alkalosis). So, simply......it just depends if the problem is in the kidneys or the lungs? And if both (bicarb and paC02) are acidotic or alkalotic, then that system that both are failing correct and not necessarily influencing each other?
Sorry that was so long and wordy. Let me know if my understanding is correct. Fix anything I might hold said wrong and add anything you would like to or you think I should know/understand. Thanks surrounded by advance.
Answers:
It sounds like you are on the right track in your comprehension for the most part of a set.
First of all just to define them both, the PaCO2 or pCO2 is representative of partial CO2 pressure and you are correct next to your normal range of 35-45 torr.
CO2 on the other hand is the manoeuvre of Carbon Dioxide, and the normal range for an adult is 23-30 mmol/L.
So the PaCO2 is a test of pressure and the CO2 is a measure of the actual dissolved gas within the blood matrix and that is directly connected to the amount of HCO3 in the blood, as dissolved CO2 takes on the form of HCO3.
You can look at Winter's Formula to understand the relationship between HCO3 (CO2) and PaCO2:
Calculated PaCO2 within Metabolic Conditions
Metabolic Acidosis with expected compensation
PaCO2 = 1.5 x HCO3 + 8 (+/- 2)
Metabolic Alkalosis with expected compensation
PaCO2 = 0.7 x HCO3 + 20 (+/- 1.5)
So as you can see from the above formulas, whenever the levels of HCO3 (CO2) transform, then so will the calculated measure of PaCO2.
As for the rest of your question, I will run ahead and let a nephrologist (if one is out there) take a stab, because they will most likely know how to help in this area, as they will own much more experience with blood gases and what can and cannot happen. Source(s): Toxicologist
serum co2 is indistinguishable as bicarb. basically, they do that just to confuse you. if serum co2 go up, bicarb goes up.
correct. if both the lungs and the kidneys are failing, there will a mixed acidosis as they cant compensate for each other. or if kidneys are working, within a few days you could see more bicarb to compensate for respiratory acidosis.
youve got it!
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For the paC02 from arterial blood gases, I know the normal value 35-45 mmHg. I take to mean if it's above that value it's considered acidotic and below alkalotic. The value comes from the dissolved C02 in the plasma solely.
For C02 content of serum chemistry panel, the normal range is 23.2-27.2 mEq/L. It comes from the dissolve CO2 in plasma and the bicarbonate within the plasma.
***Make sure I'm correct on this: If the C02 content (from chem panel) goes up, then the amount of bicarbonate has increased and if decrease C02 content..then bicarbonate decrease. Is that correct and necessarily true all the time?
And for the relationship of paC02 and bicarbonate....it a moment ago depends on what is happening: eg) The amount of bicarbonate could be alkalotic to deal with an acidotic amount of paC02 to correct the pH (correction of resp acidosis or corrected metabolic alkalosis). So, simply......it just depends if the problem is in the kidneys or the lungs? And if both (bicarb and paC02) are acidotic or alkalotic, then that system that both are failing correct and not necessarily influencing each other?
Sorry that was so long and wordy. Let me know if my understanding is correct. Fix anything I might hold said wrong and add anything you would like to or you think I should know/understand. Thanks surrounded by advance.
Answers:
It sounds like you are on the right track in your comprehension for the most part of a set.
First of all just to define them both, the PaCO2 or pCO2 is representative of partial CO2 pressure and you are correct next to your normal range of 35-45 torr.
CO2 on the other hand is the manoeuvre of Carbon Dioxide, and the normal range for an adult is 23-30 mmol/L.
So the PaCO2 is a test of pressure and the CO2 is a measure of the actual dissolved gas within the blood matrix and that is directly connected to the amount of HCO3 in the blood, as dissolved CO2 takes on the form of HCO3.
You can look at Winter's Formula to understand the relationship between HCO3 (CO2) and PaCO2:
Calculated PaCO2 within Metabolic Conditions
Metabolic Acidosis with expected compensation
PaCO2 = 1.5 x HCO3 + 8 (+/- 2)
Metabolic Alkalosis with expected compensation
PaCO2 = 0.7 x HCO3 + 20 (+/- 1.5)
So as you can see from the above formulas, whenever the levels of HCO3 (CO2) transform, then so will the calculated measure of PaCO2.
As for the rest of your question, I will run ahead and let a nephrologist (if one is out there) take a stab, because they will most likely know how to help in this area, as they will own much more experience with blood gases and what can and cannot happen. Source(s): Toxicologist
serum co2 is indistinguishable as bicarb. basically, they do that just to confuse you. if serum co2 go up, bicarb goes up.
correct. if both the lungs and the kidneys are failing, there will a mixed acidosis as they cant compensate for each other. or if kidneys are working, within a few days you could see more bicarb to compensate for respiratory acidosis.
youve got it!
Related Questions: