How do diuretics oblige next to dignified blood pressure?
I understand the kidney filters blood, and I understand diuretics increase the amount of river lost in urine/increase the frequency of urination. How does this exactly affect the blood pressure though? I assume it has something to do with the exchange of ions within the nephron. I understand that blood pressure is the amount of pressure being exerted on the arterial walls and BP= cardiac output x total peripheral resistance. I cannot follow how the nephrons can influence that though if that's how it works at all.
Also, do diuretics necessarily increase this filtration process as a whole or does it just affect the adsorption/secretion of ions/molecules involved?
Hope someone can put this together for me to better apprehend it. Thanks in advance.
Answers:
Not sure but fluids don't compress as much as oxygen, so possibly it has something to do with the reduction of fluids contained by your system just a guess but ask a pharmacists they know all about meds.
Different classes of diuretics affects different parts of the nephron to increase the loss of fluid and solutes. For example, some works by affecting channel in the loop of henle, some works by affecting action of hormones such as aldosterone on the nephrons. I don't think diuretics affects the filtration at the glomerulus, it affects the absorption/secretion.
In the equation BP = CO x TPR. Cardiac output (CO) itself depends on assorted factors. One of them is the blood volume.
Another thing is that there also exists this relationship:
Pressure within a blood vessel = (blood volume)/(compliance)
so increase in blood volume would increase the pressure on the vessel wall. Source(s): school...
Thank you for the question.
Scott, please don't fret. The answer to your request for information is not complicated.
Simply, most diuretics lower blood pressure through two mechanisms: direct vasodilation and by decreasing intravascular blood volume through diuresis. The latter effect is straightforward; the above responders have given good physiologic explanations for this works. However, most lay persons do not understand that vasodilatation may be the dominant effect, depending on the particular diuretic and dosage.
The prototypical example is hydrocholorothiazide (HCTZ). At a low dosage of 12.5 mg on a daily basis, HCTZ exerts its effect predominantly through vasodilation of the smooth muscles of the peripheral arterial circuit. Whereas, at a higher dosage (25 mg daily), HCTZ lowers blood pressure through both vasodilation and diuresis.
Lasix works similarly, although its diuretic effect is more potent than its vasodilator effect, which in turn, is more prominent within the peripheral venous circuit.
(As an aside, the peripheral venous dilatation of Lasix explains why it is very impressive in treating cardiogenic pulmonary edema via its reduction in preload.)
Other classes of diuretics, such as spironolactone, triamterene, and amiloride, lower blood pressure predominantly though plain diuresis and reduced intravscular blood volume. Source(s): My remote medical training.
the short answer is the less fluid in your body, the easier it is for the heart to pump blood through the system, thus lowering the blood pressure.
it is a long process.
i need to clarify it. if you can own a chat with me to declare all for you communicate me. here is the id: sampad59(a)yahoo.com
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but if you can't tell me to simplify it here
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Also, do diuretics necessarily increase this filtration process as a whole or does it just affect the adsorption/secretion of ions/molecules involved?
Hope someone can put this together for me to better apprehend it. Thanks in advance.
Answers:
Not sure but fluids don't compress as much as oxygen, so possibly it has something to do with the reduction of fluids contained by your system just a guess but ask a pharmacists they know all about meds.
Different classes of diuretics affects different parts of the nephron to increase the loss of fluid and solutes. For example, some works by affecting channel in the loop of henle, some works by affecting action of hormones such as aldosterone on the nephrons. I don't think diuretics affects the filtration at the glomerulus, it affects the absorption/secretion.
In the equation BP = CO x TPR. Cardiac output (CO) itself depends on assorted factors. One of them is the blood volume.
Another thing is that there also exists this relationship:
Pressure within a blood vessel = (blood volume)/(compliance)
so increase in blood volume would increase the pressure on the vessel wall. Source(s): school...
Thank you for the question.
Scott, please don't fret. The answer to your request for information is not complicated.
Simply, most diuretics lower blood pressure through two mechanisms: direct vasodilation and by decreasing intravascular blood volume through diuresis. The latter effect is straightforward; the above responders have given good physiologic explanations for this works. However, most lay persons do not understand that vasodilatation may be the dominant effect, depending on the particular diuretic and dosage.
The prototypical example is hydrocholorothiazide (HCTZ). At a low dosage of 12.5 mg on a daily basis, HCTZ exerts its effect predominantly through vasodilation of the smooth muscles of the peripheral arterial circuit. Whereas, at a higher dosage (25 mg daily), HCTZ lowers blood pressure through both vasodilation and diuresis.
Lasix works similarly, although its diuretic effect is more potent than its vasodilator effect, which in turn, is more prominent within the peripheral venous circuit.
(As an aside, the peripheral venous dilatation of Lasix explains why it is very impressive in treating cardiogenic pulmonary edema via its reduction in preload.)
Other classes of diuretics, such as spironolactone, triamterene, and amiloride, lower blood pressure predominantly though plain diuresis and reduced intravscular blood volume. Source(s): My remote medical training.
the short answer is the less fluid in your body, the easier it is for the heart to pump blood through the system, thus lowering the blood pressure.
it is a long process.
i need to clarify it. if you can own a chat with me to declare all for you communicate me. here is the id: sampad59(a)yahoo.com
give me an im and i will tell you adjectives.
but if you can't tell me to simplify it here
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