Potassium, ventolin, insulin and glucose....? backing !?
Hi everyone,
I have been told by a Nurse Unit Manager from Accident and Emergency that when a patient is admit with high K+ (potassium) levels, they administer:
1. Ventolin
2. Insulin and glucose
3. Resonium
Can anyone explain the foundation why these three things actually lower the Potassium level? and how? what does these things actually to do lower the potassium level?
I would really appreciate any help, and thanks in mortgage for your responses !
Kind regards
Answers:
Insulin and Glucose.
EDIT: Assuming No DKA, or Frank Hyperglycemia.
Potassium is measured in the serum but is primarily an intracellular electrolyte. The drugs you mention help to temporarily drive the potassium back into the cell. Severely elevated potassium level can cause cardiac rhythm disturbances.
1) K+ is essentially an intracellular cation, so getting it into cells and hence out of the blood is an effective method for lowering K+ level. Ventolin (salbutamol) is a beta-2 agonist, and one of its actions is to drive K+ into cells.
2) The cell membrane also has an ion transport guide which co-transports both glucose and K+ into the cell.
Therefore, giving glucose will increase how much this transporter works. The insulin is to help speed this up, as insulin acts to drive glucose into cells.
3) Resonium is a drug which is not obsessed by the body, but acts within the digestive tract to decrease the digestion of K+. This means that it acts slower than the other 2 methods.
I hope that helps! (I wasn't sure how simple or complex to sort this answer...)
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I have been told by a Nurse Unit Manager from Accident and Emergency that when a patient is admit with high K+ (potassium) levels, they administer:
1. Ventolin
2. Insulin and glucose
3. Resonium
Can anyone explain the foundation why these three things actually lower the Potassium level? and how? what does these things actually to do lower the potassium level?
I would really appreciate any help, and thanks in mortgage for your responses !
Kind regards
Answers:
Insulin and Glucose.
EDIT: Assuming No DKA, or Frank Hyperglycemia.
Potassium is measured in the serum but is primarily an intracellular electrolyte. The drugs you mention help to temporarily drive the potassium back into the cell. Severely elevated potassium level can cause cardiac rhythm disturbances.
1) K+ is essentially an intracellular cation, so getting it into cells and hence out of the blood is an effective method for lowering K+ level. Ventolin (salbutamol) is a beta-2 agonist, and one of its actions is to drive K+ into cells.
2) The cell membrane also has an ion transport guide which co-transports both glucose and K+ into the cell.
Therefore, giving glucose will increase how much this transporter works. The insulin is to help speed this up, as insulin acts to drive glucose into cells.
3) Resonium is a drug which is not obsessed by the body, but acts within the digestive tract to decrease the digestion of K+. This means that it acts slower than the other 2 methods.
I hope that helps! (I wasn't sure how simple or complex to sort this answer...)
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