Thiamine fewer HARD QUESTION?
Thiamine (vitamin B1) is an important cofactor in one of the reactions within the Krebs cycle and also the reaction that converts pyruvate to acetyl CoA. It is normally found in the diet contained by yeast, pork, legumes, cereal grains, rice. It may decome deficient during malnutrition or conditions that end in malnutrition such as alcoholism, HIV, and anorexia nervosa.
QUESTION: How will cell respiration be affected? What symptoms will be observed??
Answers:
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The coenzyme form in the mentioned reaction is Thiamidine PyroPhospate (TPP). Needed in reaction of Pyruvate Dehydrogenase complex that converts pyruvate to acetyl coa and that of alpha-ketoglutarate dehydrogenase complex in Krebs cycle
Diseases: Beri-Beri (Dry, Wet or Infantile) and Wernicke-Korsikoff Psychosis syndrome (seen surrounded by chronic alcoholics with thiamine def).
Symptoms of beri-beri in general: Neurological symptoms, nausea, severe listlessness. Cardiovascular, nervous, and gastrointestinal systems also affected. Edema seen within Wet Beri-beri only.
How it affects respiration: PBecause pyruvate canNOT be converted to acetyl-CoA due to lack of TPP, pyruvate will be converted to lactic acid lower than anaerobic glycolysis. So LACTIC ACID as well as PYRUVATE accumulate (cuz pyruvate is not removed via Krebs cycle)excess lactic acid will front to lactic acidosis, which affects the brain and cardiovascular system. Source(s): http://en.wikipedia.org/wiki/Beri-beri
i learned this last month. remember it vaguely cuz i'm on holiday right in a minute after the exams.
Thiamine stores can be depleted within 1 month, but it's pretty exceptional these days. When it does, it's generally due to insufficient caloric intake (starving.)
In North America, many alcoholic beverages are fortified beside B1 precisely to prevent this problem. Depending on the severity of the alcoholism, the fortified B1 may or may not be sufficient.
Frank B1 deficiency is called BERI-BERI. Classic presentation includes: resting tachycardia (fast heart rate), impediment, and symmetric decreased deep tendon reflex; some people develop a peripheral neuropathy (usually starts with numbness/tingling surrounded by fingers and toes.)
Another presentation would be "Wernicke encephalopathy" - this presents with an orderly sequence of symptom onset: vomiting, involuntary eye movements, fever, ataxia (uncontrolled skeletal muscle movement), and progressive mental impairment.
While some of the symptoms can be reversed beside treatment, many of the neurological sequelae are permanent. Source(s): Naturopathic Doctor
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QUESTION: How will cell respiration be affected? What symptoms will be observed??
Answers:
It's obvious Nirja is a stalker, and has no idea what she is chitchat about. And also Kinjal, nice profile picutre. And Nirja, no more touching, and you're lucky you got a piece of gum.
The coenzyme form in the mentioned reaction is Thiamidine PyroPhospate (TPP). Needed in reaction of Pyruvate Dehydrogenase complex that converts pyruvate to acetyl coa and that of alpha-ketoglutarate dehydrogenase complex in Krebs cycle
Diseases: Beri-Beri (Dry, Wet or Infantile) and Wernicke-Korsikoff Psychosis syndrome (seen surrounded by chronic alcoholics with thiamine def).
Symptoms of beri-beri in general: Neurological symptoms, nausea, severe listlessness. Cardiovascular, nervous, and gastrointestinal systems also affected. Edema seen within Wet Beri-beri only.
How it affects respiration: PBecause pyruvate canNOT be converted to acetyl-CoA due to lack of TPP, pyruvate will be converted to lactic acid lower than anaerobic glycolysis. So LACTIC ACID as well as PYRUVATE accumulate (cuz pyruvate is not removed via Krebs cycle)excess lactic acid will front to lactic acidosis, which affects the brain and cardiovascular system. Source(s): http://en.wikipedia.org/wiki/Beri-beri
i learned this last month. remember it vaguely cuz i'm on holiday right in a minute after the exams.
Thiamine stores can be depleted within 1 month, but it's pretty exceptional these days. When it does, it's generally due to insufficient caloric intake (starving.)
In North America, many alcoholic beverages are fortified beside B1 precisely to prevent this problem. Depending on the severity of the alcoholism, the fortified B1 may or may not be sufficient.
Frank B1 deficiency is called BERI-BERI. Classic presentation includes: resting tachycardia (fast heart rate), impediment, and symmetric decreased deep tendon reflex; some people develop a peripheral neuropathy (usually starts with numbness/tingling surrounded by fingers and toes.)
Another presentation would be "Wernicke encephalopathy" - this presents with an orderly sequence of symptom onset: vomiting, involuntary eye movements, fever, ataxia (uncontrolled skeletal muscle movement), and progressive mental impairment.
While some of the symptoms can be reversed beside treatment, many of the neurological sequelae are permanent. Source(s): Naturopathic Doctor
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