How long does tramadol stay within your system?
Answers:
Take the half life of the drug (see Abe and Happy's answers) and multiply which ever number by 7. That gives you the number of hours formerly the drug reaches zero (by all practical measures). If you are asking nearly how long it stays before it has not efffect or cannot be detected, that's a different story. That answer would be much less. It also depends on whether you are measure tramadol in blood or urine. In urine, much longer. Source(s): Forensic psychopharmacologist
After 4 half-lives then (1/2)^4 = 0.0625 or 6.25% is left.
After 5 half-lives after (1/2)^5 = 0.03125 or 3.125 % is left.
Tramadol is listed as having a 6 hour partly life, and its active metabolite as 7.5 hours. Different studies would not be expected to come up with like numbers because of variation in individuals. Another reference give 8 hours with a range is 6 to 12 hours for the half-life.
These are mathematical models, within theory no drug every totally leaves the system, according to the models.
So 4 half lives would be 24 hours for Source(s): Goodman and Gilman's Pharmacological Basis of Therapeutics, 11th edition, page 566
Half-life elimination: Tramadol: ~6-8 hours; Active metabolite: 7-9 hours; prolonged contained by elderly, hepatic or renal impairment; Zytram(R) XL: ~16 hours; RaliviaTM ER, TriduralTM: ~5-9 hours Source(s): Lexi-Comp
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